Deployment with Python refers to the process of making a Python application available for use in a production environment. This involves packaging the application, configuring the necessary server infrastructure, and ensuring that all dependencies are properly managed. Deployment can take various forms, including using bare metal servers, virtualized servers, or platform-as-a-service (PaaS) solutions. Each method has its own advantages and challenges, and the choice often depends on the specific needs of the project. Understanding deployment is crucial for developers to ensure their applications run smoothly and efficiently in real-world scenarios.