WSGI (Web Server Gateway Interface) and ASGI (Asynchronous Gateway Interface) are both interfaces that facilitate communication between web servers and Python web applications, but they differ significantly in their design and capabilities.

WSGI is synchronous in nature, meaning it processes one request at a time. This can lead to longer processing times when handling multiple requests simultaneously, as the application must complete the current request before moving on to the next. WSGI is widely adopted and has been used by many major platforms, such as Reddit and Instagram, making it a mature and stable choice for web applications ¹².

On the other hand, ASGI is designed to support asynchronous programming, allowing applications to handle multiple requests concurrently. This leads to shorter processing times and improved performance under load. ASGI is less widely adopted than WSGI but is gaining traction, especially for applications that require real-time features, such as Discord and Twitch ¹².

In summary, the choice between WSGI and ASGI largely depends on the specific needs of your application, particularly regarding synchronous versus asynchronous processing.