WSGI (Web Server Gateway Interface) and ASGI (Asynchronous Gateway Interface) are both interfaces that facilitate communication between web servers and Python web applications.

WSGI is the older of the two and is synchronous in nature, meaning it processes one request at a time. This can lead to longer processing times when handling multiple requests simultaneously. WSGI is widely adopted and used by many major platforms, including Reddit, Instagram, and Spotify. However, it does not support asynchronous programming, which can be a limitation for applications that require handling multiple requests concurrently ¹².

On the other hand, ASGI is designed to support asynchronous programming, allowing applications to handle multiple requests simultaneously without waiting for one to finish before starting another. This can significantly improve performance in scenarios with high traffic. ASGI is newer and has seen adoption in applications like Discord and Twitch, but it has a lower adoption rate compared to WSGI ¹².

In summary, the choice between WSGI and ASGI depends on the specific needs of your application, particularly regarding synchronous versus asynchronous processing.